摘要
氨氯地平治疗１５２例（男性９８例，女性５４例）高血压病病人，每日早餐后５－１０ｍｇ，ｐｏ，疗程４ｗｋ。并与尼群地平１０ｍｇ，ｐｏ，ｂｉｄ或ｔｉｄ，４ｗｋ治疗高血压病病人６１例（男性３５例，女性２６例）作比较。结果氨氯地平组降压显效率７０．４％，有效率１６．４％，显著高于尼群地平组（显效率５３％，有效率３２％），Ｐ＜０．０５。不良反应２组类似，主要有潮红、心悸、头晕及踝肿，总发生率以氨氯地平组为少。
The antihypertensive effect of amlodipine was observed in 152 patients(M 98, F54) with hypertensive disease and compared with nitrendipine in 61 patients(M 35,F 26). Amlodipine 5-l0 mg po once daily was compared with nitrendipine 10 mg po twice to three times daily for 4 wk. The results showed that the response rate to amlodipine therapy was significantly higher than that of nitrendipine(amlodipine group: remarkable response 70.4%, response 16.4%. Nitrendipine group: remarkable response 53% response 32%, Ridit test U=2.077, P<0.05). The adverse effects of amlodipine were fewer than those of nitrendipine(16.5 % vs 23 %). The main adverse effects were flushing, palpitation, dizziness and edema of ankle in both groups.
出处
《新药与临床》
CSCD
北大核心
1995年第4期214-217,共4页
