摘要
报道６例行胰管引流病人应用４种抗生素后的血清杀菌效价（ＳＢＡ）和胰液杀菌效价（ＰＢＡ）。结果：头孢哌酮（ＣＰＺ）的ＳＢＡ和ＰＢＡ最高，哌拉西林（Ｐｉｐ）较高；头孢唑林（ＣＺ）对金黄色葡萄球菌的ＳＢＡ和ＰＢＡ较高；对肠杆菌科细菌作用较弱；氨苄西林（Ａｍｐ）的ＰＢＡ低于治疗水平。提示ＣＰＺ和Ｐｉｐ可能为治疗胰腺感染最有效的药物。
We reported the bactericidal activities of 4 antibiotics in serum(SBA)and in pancreatic juice(PBA)in 6 patients undergone pancreatoduodenectomy and pancreatic ductdrainage,The results showed that both SBA and PBA of cefoperazone)were the highest;and of piperacillin(Pip)were relatively high against 36 strains of pathogens isolated. The bactericidal activities of CPZ and Pip lasted more than 8 h.The activity of cefazolin(CZ)was high only against SpahSlOcoccSs aSreSs,but was low against EnSerobacSeriaceae and showed no effect on PseSdomonas serSginosa.The peak of SBA of ampicillin(Amp)was relatively high,and that of PBA was low. Amp showed no activity against PseSdomonas aersSinosa.It is suggested that CPZ and Pip are the drugs of choice in the treatment of bacterial infections of pancreas.
出处
《新药与临床》
CSCD
北大核心
1995年第1期28-31,共4页
关键词
头孢哌酮
哌拉西林
头孢唑林
氨苄西林
cefoperazone
piperacillin
efazolin
ampicillin
pancreatic juice
microbial sensitivity tests
serum bactericidal test
