摘要
目的 研究溃疡性结肠炎(UC)和克隆病(CD)患者T抑制细胞的活性及其临床意义。 方法 UC 13例,CD 10例及正常对照12例,从末梢血分离淋巴细胞,用刀豆素A诱导T抑制细胞活性,测定抑制指数。 结果 正常人抑制指数为2.44±0.46((?)±s),UC为1.52±0.65,CD为1.32±0.45,统计学差别非常显著(P<0.05)。 结论 肠道炎症性疾病患者T抑制细胞活性比正常人明显降低。
AIM To study on the alterations of T suppressor cell function in patients with ulcerative colitis (UC) and Crohn's disease (CD) and their clinical significance.METHODS Peripheral blood lymphocytes were separated from 13 patients with UC and 10 CD. ConA induced suppressor cell activity expressed as suppressor index (SI) was measured by short- lived suppressor cell assay. Twelve normal subjects were also tested as controls. RESULTS The SI in normal persons was 2.44±0.46(x± s), in UC; 1. 52±0.68; in CD, 1.32±0.45 (P<0.05).CONCLUSTION The suppressor -cell activity in UC and CD is significantly decreased, compared with the normal individuals.
关键词
抑制细胞活性
克隆病
结肠炎
溃疡性
suppressor cell activity ulcerative colitis Crohn's dis-ease
