摘要
本文用银染——G带复合法对胃癌前病变、胃癌患者与正常人的银染核仁形成区(Ag-NOR)作对比研究,结果表明胃粘膜中～重度肠上皮化生或不典型增生的患者,亦如胃癌,有第14号染色体Ag—NOR频率明显减少;在低分化、溃疡型、直径小于5cm的胃癌患者,第15号染色体的Ag—NOR频率减少。提示淋巴细胞Ag—NOR检查可望成为检测肿瘤高风险人群、探索疾病早期诊断、观察肿瘤对机体影响的一种手段。
With a combined method of Ag-staining and G-banding. the activities ofnucleolar organizer regions (NOR) in the lymphocytes of patients with precancerous or cancerous lesions of the stomach were studied , along with controls. The result obtained showed that the patients with moderate-severe intestinal metaplasia or atypical hyperplasia in gastric presented significant lower frequency of Ag-NOR in chromosome 14, , just like the patients with gastric cancer. In the patients with gastric cancer of hypo-differentiation or ulcer type or smaller than 5cm in diameter, the frequency of Ag-NOR in chromosome 15 was lower. These finding indicate that the Ag-NOR analysis of lymphocytes may be a measure to inspect the persons for cancer at risk, to explore early diagnosis, and to observe the effects of cancers on human body.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1989年第5期335-337,共3页
Chinese Journal of Cancer
