摘要
扑尔敏和息斯敏对缩宫素、前列腺素（ＰＧＦ２α）所致大鼠、家兔离体子宫平滑肌收缩均有明显的抑制作用，并使其张力降低，对它们的自发性收缩也具有同样作用，呈明显剂量依赖性，在较大剂量下（扑尔敏７．８×１０－４ｍｏｌ／Ｌ息斯敏１×１０－４ｍｏｌ／Ｌ）可完全取消缩宫素（５Ｕ／Ｌ）、ＰＧＦ２α（１×１０－６ｍｏｌ／Ｌ）诱发的子宫收缩，并使子宫静息能力降至最低点。以上作用可能是由于对于子宫平滑肌直接作用所致。
The isolated rat and rabbit uterus contraction induced by oxytocin(Oxy) and PGF2α were markedly inhibited;uterus resting tension was decreased and their spontaneous contractions were also inhibited after adminstration of chlorpheniramine(Chl) or astemizolum(Ast).The inhibitory effects of both drugs were dose-dependent.Under higher concentration,Chl at 7.8x104mol/L or Ast at 1x10-4mol/L could remove the uterus contraction induced by Oxy,PGF2α and cause the resting tension to decrease to the lowest level.The mechanism of their non-specific relaxing action on uterus could not be explained only by their H1-receptor blocking action.
出处
《同济医科大学学报》
CSCD
北大核心
1995年第3期184-186,共3页
Acta Universitatis Medicinae Tongji
关键词
扑尔敏
息斯敏
子宫收缩
缩宫素
前列腺素
chlorpheniramine
astemizolum
oxytocin
prostaglandins
uterus contraction
