摘要
报道19例梗阻性黄疸(A)组和10例单纯胆囊结石(B)组的IL-2、C_3、C_4和PVBF水平变化,并对A组中BTP、PVBF与IL-2、C_3、C_4关系进行分析。A组根据阻塞性质分为A_1组(恶性梗阻)和A_2组(良性梗阻)。结果显示A_1组TB、BTP显著高于A_2组(P<0.01);A_1、A_1、B组IL-2、C_3、C_4、PVBF方差分析显示有显著差异(P<0.05或P<0.01),除A2与B组C_3外(P>0.05);TB、BTP与IL-2、C_3相关分析呈显著负相关(P<0.05或P<0.01);PVBF与IL-2、C_3相关分析呈显著正相关(P<0.05或P<0.01)。结果表明梗阻性黄疸时机体的细胞免疫功能明显降低,可能由于肝脏活性的巨噬细胞功能降低和抑制性巨噬细胞被活化,导致淋巴细胞活性降低。
Interleuk]n-2(IL-2)>complement-3,4(C3,C,,)and portal vein blood flow (PVBF) had been studied in 19 pa-tients with obstructlve jaundice (group A)and 10 cases of simple gallbladder stones(group B) ,and relationship be-tween biliary tract pressure(BTP),PVBF and IL-2,C3,C4 had been analysed in group A- Group A was sub-grouped into group Al(malignant obstruction)and group A2(benign obstruction)according to the nature of the obstruction. The findings showed that serum total bihrubin(TB) and BTP in group Al were significantly hlgher than those in group A2 (P< 0. 01). Variance Anova analysis exhibited highly significant differences between group A1.A2 and B in IL-2,C3,C, and PVBF(P<0. 05 or 0. ODexcept C3 between group A2 and group B (P> 0. 05). The regressive analysis indicated that TB and BTP were negatively related with IL-2 and C3(P<0. 05 or 0. 01). The results indicated that function of cellular immunity was reduced in obstructive jaundice. The lympho-cytes activity redution may be resulted from reduced function of hepatic macrophages and the activating of sup-pressive macrophapes.
出处
《天津医药》
CAS
1995年第12期717-720,共4页
Tianjin Medical Journal
关键词
梗阻性黄疸
胆道压力
门静脉血流
白细胞介素
obsrtuctive jaundice biliary tract pressure portal vein blood flow cellular immunity
