摘要
在临床上检验红细胞的变形能力已广泛作为诊断的辅助手段。检验方法之一是让红细胞稀悬浮液在等负压下通过核孔滤膜过滤。本文针对这一试验提出了一个生物流体力学模型,用两个参数β和ε来描述红细胞的变形能力,其中β是红细胞通过单个孔时的相对阻力,ε是红细胞使孔堵塞的概率。本文揭示了这两个参数对于过滤流量随时间变化规律的不同影响。根据这一不同点,本文导出了简单的公式可由实验数据算出β和ε。理论计算曲线与实验数据对比表明,本文提出的双参数模型能比通常采用的单个总体参数“过滤指数”(IF)更全面细致地描述红细胞变形能力。
<ABSTRACT>
The red cell deformability (RCD ) has been widely tested and taken
as a diagnostic aid in clinical practice. One of such tests is the filtra-
tion of dilute red cell suspension through a nucleopore filter under con-
stant suction pressure. For this test the present paper proposes a biofluid
mechanical model, in which the RCD are discribed by two parameters,
the relative resistance 6 of a red cell passing a single pore and the
probability ε of its plugging the pore. Different effects of the two para-
meters on the change of filtration flux with time are demonstrated. Ba-
sed on this difference, simple formulas are derived to compute β and ε
from the experimental data. Comparison between the theoretically comp -
uted curves and the experimental data shows that the two-parameter
modek proposed herein can describe the RCD more comprehensively and in
more details than the traditional global parameter 'filtration index'
(IF ).
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
1989年第2期86-95,共10页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金资助项目
关键词
核孔滤膜
红细胞
生物流体力学
Biomedical Engineering
Diagnosis
Filtration
Mathematical Models
Probability
