摘要
本文作者对６７例恶性肿瘤患者同时作了血清铜（ＳＣｕ）、锌（ＳＺｎ）、硒（ＳＳｅ）含量和血红细胞超氧化物歧化酶（ＲＢＣ－ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－ｐｘ）活性及维生素Ｅ、丙二醛（ＭＤＡ）含量测定。对其中２１例肺癌和２２例胃、肠癌作了血清Ｃｕ、Ｚｎ－ＳＯＤ，Ｍｎ－ＳＯＤ活性测定，此外还对胃肠癌组织作了Ｃｕ、Ｚｎ、Ｓｅ、ＭＤＡ含量和Ｃｕ、Ｚｎ－ＳＯＤ，Ｍｎ－ＳＯＤ活性测定。结果提示恶性肿瘤患者体内ＳＣｕ升高和ＳＳｅ降低同时有氧自由基清除障碍（ＲＢｃ－ＳＯＤ，血清ＧＳＨ－Ｐｘ活性下降，ＭＤＡ含量增高），Ｓｅ和维生素Ｅ的变化可能与ＧＳＨ－Ｐｘ变化有关，Ｃｕ的变化在肺癌与Ｃｕ、Ｚｎ—ＳＯＤ似有一定关系。
Serum copper (SCu ),zinc (SZn),Selenium(SSe ) levels,red blood cell
superoxide dismutase(RBC SOD),blood glutathione peroxidase (GSH Px) activities and
Vitamin E (VitE),malondialdehyde (MDA)contents were measured si-multaneously in 67 patients
with malignant tumor. Among them 21 caese with lung cancer and 2 2 casese with
gastroentericcarcinoma were examined in serum Cu,Zn SOD,Mn SOD activities, In addition,
the levels of Cu,Zn,Se,MDA and the ac-tivities of Cu Zn SOD,Mn-SOD in gastroenteric cancer
tissues were measured.These findings suggest that in malignant tu-mor patients there are SCu
increasing and SSe decreasing, meanwhile oxygen free radicals eliminating obstructively (RBC
SOD and blood GSH Px activities were decreased , MDA contents were increased).The Variety
of Se and Vit E may be con-cerned with the variety of GSH Px,In lung cancer the variety of Cu
may be concerned with Cu, Zn SOD.
出处
《实用癌症杂志》
1995年第4期231-233,共3页
The Practical Journal of Cancer
