摘要
本文制备了聚谷氨酸苄酯膜，并进行皂化，得到了谷氨酸苄酯－谷氨酸共聚物膜．研究了不同聚合物膜对两种抗癌药物５－氟脲嘧啶（５Ｆｕ）及２－羟乙基－氧甲基－５－氟脲嘧啶（２－ＨＥＯＭ－５－ＦＵ）的渗透性能。结果表明Ｐ１（ＢＬＧ－ＬＧＡ）膜渗透５－Ｆｕ和２－ＨＥＯＭ－５－Ｆｕ的渗透系数分别是ＰＢＬＧ膜的４和１６倍，且Ｐ２（ＢＬＧ－ＬＧＡ）膜的渗透系数分别是ＰＢＬＧ膜的１３和２６倍．
The membranes of poly(benzenyl L-glutamate-co-L-glutamic acid ) were prepared by saponitfication of poly(benzenyl L-glutamate) membrane. The permeation of two anti-cancer drugs of 5-fluoro-uracil (5-Fu) and 2-hydroxy-ethyl-oxy-methyl-5-fluoro-uracil (2-HEOM-5-Fu ) through these membranes was studied. The results showed that the permeation coefficients of 5-Fu and 2-HEOM-5-Fu through P1 (BLG-LGA) membrane were 4 and 16 times larger than those of PBLG membrane respectively, and those through P2 (BLG-LGA) membrane were 13 and 26 times larger than those of PBLG membrane respectively.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
1995年第3期187-190,共4页
Journal of Biomedical Engineering
关键词
聚谷氨酸苄酯膜
抗癌药物
PBLG membrane
P (BLG-LGA ) membrane
Anticancer drug
Permeation
