摘要
基因治疗研究的最新成就是非常鼓舞人心的，但是还有许多问题等待解决．首先回顾了近年来有关基因治疗的重要基础研究，包括基因导入技术的研究．后者是基础研究中最重要的课题之一，包括逆转录病毒载体和ＤＮＡ病毒载体的应用，以及非病毒学方法．其次叙述了实验模型建立的研究．最后着重讨论了遗传病，癌症和其疾病的基因治疗的策略，特别着重在爱滋病和心血管疾病基因治疗的一些策略．
The recent results in the researchof gene therapy have been encouraging,inspite of numerous problems still remaining tobe solved.The basic studies on gene therapyand the study on the techniques of the gene in-troduction are reviewed.The latter is one ofthe most important topics in basic studies, including retrovirus vectors,DNA virus vectorsas well as non-viral techniques.The recentadvances in the establishment of the experi-mental models are also described.Then therecent advances in the gene therapy of heredi-tary diseases,malignant tumors and other dis-eases are briefly discussed, especially empha-sizing the strategies of the gene therapy ofAIDS and cardiovascular diseases.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1995年第3期227-232,共6页
Progress In Biochemistry and Biophysics
关键词
基因治疗
遗传病
基因转移
心血管疾病
癌
gene therapy,genetic diseases,cancer,AIDS, cardiovascular diseases,genetransfer
