摘要
采用原位杂交组织化学技术观察了老年大鼠弓状核内生长抑素信使核糖核酸（ｍＲＮＡ）的表达。和年青大鼠相比，老年大鼠弓状核内生长抑素ｍＲＮＡ阳性胞体大多染色浅淡，与背景反差小，数量上明显减少。结果提示：在衰老过程中，弓状核内生长抑素减少可能对机体内分泌和神经内分泌功能的进行性衰退有重要作用。
Somatostatin mRNA expression in the arcuatc nucleus of aging rats was identified with in situ hybridization histochemistry. The results showed that most somatostatin mRNA-positive cells had a weak hybridization signal in the arcuate nucleus of aging rats. Moreover, the signal/noise ratio and number of positive cells were much lower in the old rats. The above mentioned results suggest the possible association of the decrease of somatostatin in the arcuate nucleus with uninterrupted decline of the eudocrine' s and neuroendocrine's functions with aging.present address.Shanghai Brain Research Institute, Academia Sinica
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1995年第4期762-764,共3页
Journal of Nanjing Medical University(Natural Sciences)
