摘要
采用比色法测定５３例新生病儿血一氧化氮（ＮＯ）代谢产物亚硝酸盐（ＮＯ２）的浓度。结果败血症为（７５．７±１６．０）μｍｏｌ／Ｌ，高胆红素血症为（７３．７±１０．８）μｍｏｌ／Ｌ，均极明显高于正常新生儿（５０．１±１４．５）μｍｏｌ／Ｌ，而缺氧缺血性脑病、肺炎和一般感染的新生儿血ＮＯ２分别为（５０．８±１６．１）μｍｏｌ／Ｌ、（５４．７±１１．０）μｍｏｌ／Ｌ和（４７．８±１２．７）μｍｏｌ／Ｌ，与正常新生儿比较无显著升高。本研究提示ＮＯ在新生儿败血症和高胆红素血症等疾病中起一定致病作用。
Nitrite(NO2)the metabolic product of nitric oxide(NO), in blood of 53 newborns was determined by spectrophotometrical method. Data showed that the blood NO2 concentrations of newborn with sepsis and hyperbilirubinemia, being 75. 7±16. 0μmol/L and 73. 7±10. 8 μmol/L respectively, were significantly higher than those of the normal newborns (50.1±14.5μmol/L). In cases of hypoxic and ischemic encephalopathy, pneumonia and mild infectious diseases, NO2 levels were 50. 8±16.1μmol/L, 54. 7±11.0μmol/L and 47. 8±12. 7 μmol/L respectively, which were not significantly higher than those of the normal newborns. These results suggest that NO might play a role in pathogenesis of some diseases(e.g.,sepsis and hyperbilirubinemia)in newborns.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1995年第4期784-785,共2页
Journal of Nanjing Medical University(Natural Sciences)
