摘要
本文从体内及体外两方面探讨了雷公藤片对小鼠脾脏抑制细胞活性的影响。雷公藤片0.2克/日/只灌胃5天及9天后,小鼠脾脏抑制细胞活性明显增高,达26.9±23.9%及37.9±22.7%;与正常对照组相比(-14.4±37.9%)差异非常显著(P<0.01)。而给药12及15天后抑制细胞活性则有的明显增高,有的明显降低。给药5天后脾细胞对ConA应答明显降低。停药后7天,小鼠脾细胞对ConA应答已部分恢复,但抑制细胞活性仍然保持在较高水平。雷公藤片体外诱导2天后的脾细胞可明显抑制正常脾细胞对ConA的应答,抑制率达47.0±14.8%。本文还对雷公藤片的作用机理加以初步探讨。
We have studied the induction of mice spleen suppressor cell activity by Trypterygium Wilfordii Hook f. both in vivo and in vitro. We detected the suppressor cell activity in mice which were administrated with the drug for different days & found that after giving the drug for 5 or 9 days, the suppressor cell activity elevated remarkly, but for 12 & 15 days, the suppressor cell activity varied indefinitely, some were higher & some were lower. The drug inhibited the response of spleen cell to Con A too. But the release of inhibition on Con A responsibility was earlier than the recovery of elevated suppressor cell activity. Cocultured with the drug, slight promotion on cell proliferation was observed. The normal spleen cells cocultured with the drug for two days suppressed the normal spleen cell proliferation stimulated by Con A, the suppressive rate was comparable to that of Con A induced suppressor celll.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1989年第2期106-109,共4页
Chinese Journal of Pathophysiology
关键词
雷公藤片
抑制细胞
脾脏
鼠
Medicine, chinese traditional
Suppressor cells
