摘要
本文对３２例系统性红斑狼疮（ｓｙｓｔｅｍｉｃｌｕｐｕｓｅｒｙｔｈｅｍａｔｏｓｕｓ，ＳＬＥ）及２５例类风湿性关节炎（ｒｈｅｕｍａｔｏｉｄａｒｔｈｒｉｔｉｓ，ＲＡ）进行了Ｎ－乙酰化转移酶多态现象和基因频率的研究。结果显示：ＳＬＥ中６例为慢反应型，基因频率Ｒ为０．５６７０，ｒ为０．４３３０；ＲＡ中１８例为慢反应型，基因频率Ｒ为０．１５１５，ｒ为０．８４８５．ＳＬＥ组与正常组无差异，ＲＡ组与ＳＬＥ组及正常组相比皆有显著性差异。实验提示中国人ＳＬＥ组与ＲＡ发病中可能有不同遗传机制参与。
systemic lupus erythematosus(SLE) and 25 rheumatoid arthritis(RA)patients were stu-died on polymorphism of N-acetyltranferase and gene freqency.Our results indicated that there are 6 slowacetylators in 32 SLE cases,as compared with 18 of the 25 RA patients,Gene freqency R is 0.5670 and r is0.4330 in SLE group,however,R is 0. 1515 and r is 0.8485 in RA group. There is significant difference be-tween SLE and RA patients,also remarkable difference between the normal and the RA cases. The resultssuggest that different genetic mechanism is probably involved in the pathogenesis of both SLE and RA.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1995年第4期246-248,共3页
Immunological Journal
