摘要
本文观察了10例冠心病(CHD)不稳定型心绞痛患者使用国产甘糖脂片治疗后血管内皮细胞损伤的敏感而又特异指标——循环内皮细胞和内皮素、血管紧张素转换酸及前列腺素I_2代谢产物6-酮-前列腺素F_(?)的动态变化,并与10例卡托普利治疗组及9例对照组进行对比.结果发现:甘糖脂对内皮细胞的保护作用与卡托普利相当,自身前后及与对照组比较均有显著意义,且副作用小.认为卡托普利是防治CHD患者内皮损伤的有效药物.
The dynamic changes of endothelin(ET) .angiotensin-converting enzyme(ACE) .6-keto-PGF18 metabolized from prostaglandin (PGI2aand circulating endothelial cells (CEC) of 10 CHD-patients with unstable angina before and after treatment with domestic progylene glycol man-nate sulfate (PGMS) were observed. The results were compared with those of 10 patients treated with Captopril and those of 9 control patients. It showed that PGMS possessed a similar protective effect on endothelial cells as Captopril. There were significant differences between the results of treated groups and control patients. It suggests that PGMS is an effective drug to protect vascular endothelial cells.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1995年第2期67-69,共3页
Journal of Clinical Cardiology
