摘要
本工作研究了巴曲酶对结扎左侧颈总动脉沙土鼠的缺血模型的保护作用以及时脑组织精氨酸加压素（ＡＶＰ）的影响及两者的相互关系。发现巴曲酶可减轻卒中症状及降低脑组织ＡＶＰ含量、卒中指数与脑组织ＡＶＰ含量呈正相关。提示ＡＶＰ可能在减轻脑卒中症状中起重要作用，以及巴曲酶能降低ＡＶＰ可能为其对于脑缺血具有保护作用的机理之一。
The protective effect of Batroxobin(TOBISHI DF-52 1)on ischemic ger-bil stroke model produced by unilateral ligation of left common carotid artery and the ef-fect of Batroxobin on cerebral concentration of arginine vasopressin(AVP)were stud-ied.It was found that the degree of severity of stroke and AVP concentration in cerebral tissue of ligated side were significantly decreased in Batroxobin-treated group.There was a significant positive correlation between stroke index and cerebral concentration of AVP. We speculate that AVP may play an important role in ameliorating the ischemic condition and one of the protective effects of Batroxobin on ICVD may be related to its effect on AVP.
出处
《临床神经病学杂志》
CAS
1995年第5期261-264,共4页
Journal of Clinical Neurology
关键词
脑缺血
巴曲酶
精氨酸加压素
Batroxobin(TOBISHI DF-521)Cerebral ischemia Arginine vaso-pressin
