摘要
利用粗制豚鼠内耳膜迷路抗原免疫豚鼠，观察内耳听功能及其形态学变化，检测血清中Ｉｇ、Ｃ＿３、ＣＩＣ及抗内耳自身抗体，并用免疫组织化学方法检测内耳切片中ＩｇＧ沉积物。结果表明，以本实验方法可在部分动物建立自身免疫性内耳损害的动物模型，为深入研究该病打下了基础。
Using crude inner ear antigen,the guinea pigs was immunized. ECochG was recorded, morphology of inner ear was observed, Ig, C_3, CIC and antibodies against the inner ear tissue in the serum were tested,and using the method of immunohistochemystry,the IgG deposition in the section of inner ear was also determined. The results showed that the animal model of autoimmuneinner ear disease in some of this experimental guinea pigs was established. This has been laid down a solid foundation for further study of this disease.
出处
《临床耳鼻咽喉科杂志》
CSCD
1995年第1期15-17,共3页
Journal of Clinical Otorhinolaryngology
