摘要
为研究不同吸入浓度七氟醚对肝脏的影响，４０只ＳＤ大鼠被随机分为四组：对照组（Ｉ组，ｎ＝１０，０ＭＡＣ）；异氟醚组（Ⅱ组，ｎ＝１０，０．５ＭＡＣ）；０．５ＭＡＣ七氟醚组（Ⅲ１组，ｎ＝１０，０．５ＭＡＣ）；０．９ＭＡｃ七氟醚组（Ⅲ２组，ｎ＝１０，０．９ＭＡＣ）。各组动物分别吸相应浓度麻醉药，３ｈ／ｄ，共６ｄ，以肝功能变化、肝组织细胞形态学改变作为评价肝脏受损指标。结果提示，七氟醚对肝脏有一定的影响，与异氟醚相似，其影响程度与用药浓度有关。
o studv the hepatotoxicity of various concentratiOn of sevoflurane,40 SD rats were divided randomly intofour groups:Control(group I,n=10,0MAC);Isoflurane(group Ⅱ,n=10,0. 5MAC);0.5MAC sevoflurane(group Ⅲ1,n=10);And 0.9MAC sevoflurane(group Ⅲ2,n=10)。Each rat was exposed to a corresponding anesthetic vapor for 3 hours per day for 6 days (totally 18 hours).The hepatic function and morphology were examinedto evaluate hepatotoxicity.The results suggest that the hepatotoxicity of sevoflurane is similar to that of isofluraneand correlated with the inhaled concentration.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
1995年第2期63-65,共3页
Journal of Clinical Anesthesiology
