摘要
本文旨在评价单剂量可乐定在国人颅脑外科手术中对异氟醚用量及围术期血流动力学的影响。２０例ＡＳＡⅠ－Ⅱ级颅脑择期手术病人随机分为两组。１组（对照组，ｎ＝１０）于术前３０ｍｉｎ给予阿托品０．５ｍｇ和苯巴比妥钠１０Ｏｍｇ肌注；Ⅱ组（可乐定组，ｎ＝１０）除１组术前用药外，另加可乐定５μｇ·ｋｇ－１于术前９０ｍｉｎ口眼。两组病人相比，可乐定组麻醉维持所需吸入、潮气末异氟醚浓度和异氟醚用量显著低于对照组（Ｐ＜０．０５），并且更能稳定麻醉诱导、置镜和插管过程中的血流动力学参数，具有一定的临床应用价值。
This study was to assess the effects of singledose clonidine premedication on isoflurane requirements and peri-operative hemodynamics in neurosurgical patients. 20 cases of ASA Ⅰ - Ⅱ were randomly divided into two groups.Group 1 (control group ,n= 10)was premedicated with atropine 0.5 mg and luminal 100mg i. m30min ,before anes-thesia;group 2 (clonidine group,n = 10) , received clonidine 5μg · kg`-1 p. o. 90min before anesthesia in addition.The results reveal that the inspired and expired isoflurane concentration of group 2 was significantly lower thanthose of control group as similar anesthetic depth was maintained,and isoflurane requirements of group 2 was sig-nificantly less. Moreover ,clonidine SPg· kg-1 p. o. premedicated 90min before intubation was more effective in sta-bilizing hemodynamics associated with laryngosopy and endotracheal intubation than control ones.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
1995年第1期7-9,共3页
Journal of Clinical Anesthesiology
