摘要
目的:研究落叶松阿拉伯半乳聚糖滴丸的制备工艺并初步探讨其速释机制。方法:采用正交设计对滴丸制备工艺进行优化,并通过相图分析和DSC分析研究滴丸的速释机制。结果与结论:滴丸制备最佳的工艺条件为药液温度75℃,二甲基硅油冷凝液上部温度30℃,滴头与冷凝液的距离6cm,滴速为30滴/min;相图分析和DSC分析结果显示在AG-PEG4000固体分散体中形成了某种形式的复合物,使熔点降低,药物在基质中的溶解度增加而达到速释。
Objective： The study is the research on the preparation of arabinogalactan （AG） dropping pills and the releasing mechanism. Method： Use the orthogonal test to find out the best way to produce and advance the preparation of AG dropping pills, analysis according to the chart and DSC to find the releasing mechanism. Result： The best preparation conditions are： the liquid of AG is at 75℃, the temperature above the polydimethls iloxane is 30℃, the distance to the frizzed liquid is 6 cm, the speed of the liquid is 30 drop·min^-1. The chart and DSC suggest： The solid disoperation of AG-PREG 4000 the complex is in a certain form which made the melting point decreased obviously, so as to increase the solution of the medicine in cartier to increase the releasing speed. Conclusion： The best preparation is reasonable, AG and carrier become a form, the melting point is low, it can release fast.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第16期1249-1251,共3页
China Journal of Chinese Materia Medica
基金
引进国际先进农业科学技术948项目(2002-4-2)黑龙江省重点项目(GB018602)
