摘要
目的:考察透明质酸钠作为双黄连滴眼液增黏剂的可行性。方法:测定pH、温度对黏度的影响,增黏剂的刺激性及稳定性。结果:pH6.0-8.0温度15℃-37℃对透明质酸钠黏度影响不大,且其温和无刺激性,性质稳定。结论:透明质酸钠性质稳定,提高了滴眼液的黏度,适合于做双黄连滴眼液的增黏剂。
Objective： To study the possibility of hyahtronic acid as densifier of Shuanguangliao eye-drops. Method： The factors related with hyahtronic acid s viscosity, such as pH-value and storing temperature, are tested in this experiment. At the same time, we checked the stimulation, stability of the densifier Result： There was not effect on viscosity of pH-value and storing temperature. No stimulation on the eye was found after densified with hyaluronic acid. The viscosity properties of hyaluronic acid are stablile. Conclusion： The hyaliuronic acid added to Shuanghuanglian eye-drops are stabiliable and it can be applied in eye-drops. The increased viscosity is benefit to extend the residence time of drug in eye.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第16期1246-1248,共3页
China Journal of Chinese Materia Medica
基金
黑龙江省科委自然科学基金课题(D00-34)
关键词
透明质酸钠
双黄连滴眼液
增黏剂
hyaluronic acid
Suanghuanglian eye-drops
densifier
