摘要
目的了解强化降糖治疗与常规降糖治疗对2型糖尿病已有血管并发症或具备血管并发症高危因素的患者尿白蛋白的影响。方法选择97例具备大血管疾病或微血管疾病的2型糖尿病高危患者,随机分为强化治疗组及标准治疗组。比较治疗前及治疗2年后的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、晨尿白蛋白/肌酐比值(Alb/Cr)、血脂、血压、体重指数(BMI)的变化。结果两组入组时FBG、HbA1c、BMI、血脂、血压、尿Alb/Cr及治疗后两组的血脂、收缩压及舒张压之间差异均无显著性(P>0·05)。治疗2年后,强化组HbA1c控制达标率显著高于标准组;两组的尿Alb/Cr较前均下降,强化治疗组下降更为明显,差异有显著性(P<0·01);低血糖次数强化组比标准组高3·33倍,无严重低血糖发生。结论进一步强化降糖治疗能更有效地减少高危糖尿病患者尿微量白蛋白,延缓肾脏功能损害。
Objective To study the impact of long-term treatments on the chronic complications of type 2 diabetic patients with risk factors. Methods Ninety-seven patients with great vessels diseases or capillary vessel diseases were randomly divided into the intensive therapy group and the conventional therapy group. The levels of FBG, HbA1 C, Alb/Cr, serum lipid metabolism, blood pressure, BMI, eyeground and acuteness of vision were analyzed. Results There was neither statistical significance in FBG, HbAlC, BMI, serum lipid metabolism, blood pressure, and Alb/Cr before treatment nor in the SBP and DBP after treatment between the two groups（P 〉 0. 05 ）. After two years＇ treatment, the level of HbA1C was controlled more satisfactory in the intensive therapy group than that in the conventional therapy group. The level of Alb/Cr was descended in both groups, but there was statistical significance in the intensive group（ P 〈0.01 ）. The episode of hypoglycemia in the intensive therapy group occurred 3.33 times as frequently as it did in the conventional therapy group. No severe epsode of hypoglycemia happened in either group. Conclusion The intensive treatment to diabetes is able to effectively reduce the urinary microalbumin（U-mal） and it is crucial for prevention of deterioration of renal function in patients with risk factors.
出处
《安徽医科大学学报》
CAS
北大核心
2005年第4期384-386,共3页
Acta Universitatis Medicinalis Anhui
基金
国际合作课题(https://www.ctru.auckland.ac.nz/ad-vance)
关键词
糖尿病
Ⅱ型/药物疗法
白蛋白尿
diabetes mellitus, type Ⅱ/drug therapy
albuminuria
