摘要
Objective： To study the relationship of local immunity in the female genital tract with the clinical course of Nongonococcal Urethritis （NGU）. Methods： We collected cervical secretions from patients and examined levels of SIgA and IFN- γ. Results： Levels of SIgA and IFN- γ in the infected group were lower than those in the uninfected group, P1〈0.05 and P2〈0.05. The level of SIgA and IFN- γ in C.t,UU and C.t＋UU infected groups were not significantly different. Comparing the negative-changed group with thenonnegative-changed group, the level of SIgA and IFN-γ was 39.22±20.04mg/L and 103.19±29.94pg/ml, 26.00±10.56mg/I and 88.21±15.10pg/ml, P1〉0.05 and P2〉0.05. Conclusion： SIgA and IFN-γ secreted by genital tractmucosa may help prevent and resist local NGU infection.However, the effect is limited, and is insufficient to eliminate infection completely and prevent reinfection.
目的初步探讨女性生殖道局部免疫与非淋菌性尿道炎(NGU)临床过程的相互关系。方法定量采集不同临床过程的NGU女性患者宫颈分泌物,检测分泌性免疫球蛋白A(SIgA)和γ干扰素(IFN-γ)的水平,分组比较。结果NGU感染组SIgA和IFN-γ的水平低于未感染组。NGU感染者中,沙眼衣原体(CT)感染组、解脲支原体(UU) 感染组和CT+UU合并感染组SIgA和IFN-γ水平没有显著性差异。NGU转阴组和未转阴组SIgA和IFN-γ水平无显著性差异,但从整体趋势上看,转阴组高于未转阴组。结论宫颈分泌物中的SIgA和IFN-γ对预防局部NGU感染有一定作用, 有助十清除局部病原菌。但SIgA和IFN-γ的局部免疫作用不强,不足以彻底清除病原体及预防再感染的发生。
