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一种周围血管内放射治疗计划的优化方法 被引量：1

Optimization of intravascular brachytherapy treatment planning in peripheral arteries
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摘要 为了促进内放射治疗技术尽早运用到PTA术后周围血管再狭窄的治疗中去,提出一种基于主动漫游的周围血管内放射治疗计划的混合优化方法。首先利用主动漫游获取血管的几何结构,然后建立数学模型对治疗计划方案进行优化。为了加快优化速度,根据待优化参数的属性,综合运用BFGS算法和模拟退火算法来进行优化。实验结果表明,采用上述方法得到了较好的剂量表面直方图,等处方剂量线与治疗区血管内表面吻合良好,并具有较快的计算速度. In order to promote the technology of intravascular brachytherapy to be applied timely in the restenosis treatment of peripheral arteries after percutaneous transluminal angioplasty （PTA）, a method combining the active navigation with optimization algorithm for the planning of peripheral intravascular brachytherapy is proposed. According to the characteristics of the vessel obtained by active navigation, a method combining the broyden-fletcher-goldfarb-shanno （BFGS） with simulated annealing algorithm is applied to optimize the number of seeds, and the parameters associated with each seed such as the position, and the dwell time. Application of the method to a phantom model and animal models of stenosis shows that qualified dose surface histogram（DSH） could be obtained within a few minutes, the iso-prescribe-dose line fits well to the inner surface of vascular within treatment region。
作者 周正东 舒华忠 P.Haigron 於文雪 罗立民
机构地区 南京航空航天大学医学物理系 东南大学影像科学与技术实验室 雷恩第一大学信号与图像处理实验室
出处 《东南大学学报（自然科学版）》 EI CAS CSCD 北大核心 2005年第4期607-610,共4页 Journal of Southeast University：Natural Science Edition
关键词 周围血管内放射 主动漫游 剂量优化 BFGS算法 模拟退火算法 intravascular brachytherapy in peripheral arteries active navigation dose optimization BFGS algorithm simulated annealing algorithm
分类号 R815 [医药卫生—放射医学] TP391 [自动化与计算机技术—计算机应用技术]
  • 相关文献

参考文献9

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二级参考文献13

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共引文献2

同被引文献46

  • 1杨瑞杰,戴建荣,胡逸民.放疗的生物学评估和优化[J].中华放射肿瘤学杂志,2006,15(3):172-175. 被引量：13
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二级引证文献3

东南大学学报（自然科学版）
2005年 第4期

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