摘要
硬膜外打击法制作创伤性脑水肿动物模型后随机分为外伤组、游离超氧化物歧化酶（Ｆ－ＳＯＤ）治疗组和脂质体包埋超氧化物歧化酶（Ｌ－ＳＯＤ）治疗组。分别观察伤后意识活动、脑电生理、血脑屏障通透性、脑组织形态学以及血清、脑脊液、脑内氧自由基、ＳＯＤ和脑中水含量的变化。结果表明，Ｆ－ＳＯＤ和Ｌ－ＳＯＤ均对创伤性脑水肿有保护作用，后者的作用更明显更持久。
Twenty-eight cats were subjected to extradural impact to produce traumatic brain edema.They were divided into three groups randomly :injury group ,free-SOD (F-SOD) treatment group and lipo-some-entrapped SOD (L-SOD) treatment group. Consciousness status, EEG ,BBB permeability ,brain wa-ter content ,histomorphology,and LPO and SOD in serum,cerebrospinal fluid and in the brain before andafter injury were observed. The results showed that both F-SOD and L-SOD displayed protective effect onposttraumatic brain edema ,and the effect of L-SOD was more marked and persistent. The preparation andcharacter of L-SOD were presented and the mechanism of the effect of these two types of SOD was dis-cussed in the paper.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1995年第5期336-338,共3页
Medical Journal of Chinese People's Liberation Army
