摘要
目的探讨帕罗西汀治疗经前紧张综合征的疗效。方法将符合经前紧张综合征诊断标准的患者随机分为研究组、对照组。研究组给予帕罗西汀,对照组给予维生素B1治疗,分别于入组时、治疗第3个月经周期,采用汉密尔顿抑郁量表(HAMD21项)、汉密尔顿焦虑量表(HAMA)评定情绪变化,用临床疗效总评量表病情严重程度(CGI-SI)和临床疗效总评量表疗效总评(CGI-GI)评定病情严重程度及疗效情况。并用自编躯体症状评定量表评定躯体症状变化。结果研究组治疗前后HAMD评分除昼夜节律因子差异无显著性外(P>0.05),HAMD总分及各因子分差异有显著性(P<0.01)。HAMA总分及各因子分、CGI-SI评分、躯体症状评定量表评分治疗前后差异均有显著性(P<0.01)。而对照组除HAMA总分、精神性焦虑因子及CGI-SI评分治疗前后差异有显著性外(P<0.05),其余量表及因子分差异均无显著性(P>0.05)。HAMD总分、HAMA总分、躯体症状评定量表评分治疗前后减分率研究组分别为63.2%、57.3%、57.8%,对照组分别为10.2%、9.7%、6.9%,上述三者治疗前后减分率比较差异有显著性(P<0.01)。结论帕罗西汀治疗经前紧张综合征疗效好,值得临床推广试用。
Objective To explore the effectiveness of paroxetine on the treatment of premenstrual tension syndrome . Methods The outpatients diagnosed as premenstrual tension syndrome were assigned to the experimental group or the control group randomly. Patients in the experimental group were given paroxetine 20～30mg/d, and the patients in the control group were given vitamine B1 60mg/d. All the patients were evaluated at the point of entrance and the third menstrual cycle after treatment with the Hamilton depression rating scale ,the Hamilton Anxiety Rating Scale ,the clinical global impression scale and the self-making somatic symptom rating scale respectively. Results 70 patients were enrolled in this study and 66 of them completed （33 in each group）. According to the experimental group, significant differences were found in the total score and factor scores of HAMD except for the diurnal rhythm factor after treatment （ t=0.86, P 〉 0.05 ）, as well as the total score and factor scores of HAMD （ t = 3.34～11.10, P〈 0.01 ） , the scores or CGI-SI and the somatic symptom rating scale（t=2.38～2.63, P 〈 0.05 ）. In ten control group however, significant differences were only found in the total score of HAMA, the factor score of mental anxiety and the score of somatic symptom rating scale . Between the two groups, significant differences were found in reducing rate of the total score of HAMD, HAMD ,and the score of somatic symptom rating scale （63.2% vs 10.2%, 57.3% vs9.7%, 57.8% vs6.9%, u =4.75～9.57, P〈0.01）.Conclusion Paroxetine has a confirmative treatment effect on premenstrual tension syndrome.
出处
《中国行为医学科学》
CSCD
2005年第8期697-698,共2页
Chinese Journal of Behavioral Medical Science
