摘要
目的:探讨缬沙坦对原发性高血压患者左心室肥厚及血管壁肥厚的影响。方法:入选原发性轻、中度高血压(EH)伴左心室肥厚(LVH)病人48例,正常血压对照(NT)组48例,EH 组给予缬沙坦80～160 mg/d,治疗40 周,治疗前后检测左室重量指数(LVMI),颈总动脉内膜中层厚度(IMT)。结果:EH 组病人LVMI、IMT 较对照组显著增厚(P<0. 01) ,缬沙坦治疗后LVMI、IMT 显著减少(P<0. 01) 。结论:EH 伴左心室肥厚的病人同时存在颈总动脉壁肥厚,缬沙坦能逆转高血压心脏及血管的重构。
Objective： This study was to explore the effect of valsartan on left ventricular hypertrophy （LVH） and the artery intima-media thickness increasing in essential hypertensive （EH） patients. Methods： Forty-eight mild to moderate essential hypertensive patients with the LVH received 80-160 mg valsartan by oral once per day for 40 weeks.Forty-eight cases with normal blood pressure were as the contrast group. Left ventricular mass index （LVMI） and the intima-media thickness （IMT） of common carotid artery were detected before and after the treatment. Results： IMT and LVMT of the EH group patients after the treatment decreased significantly （P〈0.05-0.01）. Conclusion ：Valsartan can reverse cardiovascular remodeling in EH patients with LVH and intima-media hypertrophy of common carotid artery.
出处
《心血管康复医学杂志》
CAS
2005年第4期349-350,共2页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
缬沙坦
高血压
心室重构
Valsartan
Hypertension
Ventricular remodeling
