Site-directed Chemical Modification of Recombinant Human aFGF Mutant with Polyethylene Glycol

Site-directed Chemical Modification of Recombinant Human aFGF Mutant with Polyethylene Glycol

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摘要 A new product PEGylated rhaFGF was obtained by site-directed chemical modification.When compared with unmodified rhaFGF, PEGylated rhaFGF showed comparable bioactivity and superior stability at 37℃ in mouse serum and the stronger resistant potency to trypsin. This was accompanied by a substantial decreasing tmmunogenicity.Site-specific PEGylation of rhaFGF may increase its therapeutic potency in humans. A new product PEGylated rhaFGF was obtained by site-directed chemical modification.When compared with unmodified rhaFGF, PEGylated rhaFGF showed comparable bioactivity and superior stability at 37℃ in mouse serum and the stronger resistant potency to trypsin. This was accompanied by a substantial decreasing tmmunogenicity.Site-specific PEGylation of rhaFGF may increase its therapeutic potency in humans.

作者 Qing ZHENG Zhi Feng HUANG Xiao Ping WU Zhi Jian SU Hua XU Wen ZHAO Ya Dong HUANG Xiao Kun LI

机构地区 College of Pharmacy Biopharmaceutical R＆D Center of Jinan University

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第8期1013-1016,共4页 中国化学快报（英文版）

基金 The Hi-tech Research and Development Program of China(2002AA2Z3318) Guangdong Natural Science Foundation(010424)supported this study.

关键词 rhaFGF chemical modification PEGylated rhaFGE rhaFGF, chemical modification, PEGylated rhaFGE

分类号 O629 [理学—有机化学]

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Chinese Chemical Letters

2005年第8期

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Site-directed Chemical Modification of Recombinant Human aFGF Mutant with Polyethylene Glycol

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