摘要
目的评价妊娠中期母血清生化标志物筛查唐氏综合征(21-三体综合征)的临床价值.方法 1996年7月至2003年6月,南京市妇幼保健院用时间分辨荧光分析法对13175例妊娠14～20周的孕妇进行血清甲胎蛋白(AFP)、游离绒毛膜促性腺激素(free-β-HCG)检测,切割值1∶ 300,对高风险者行羊水检查.结果 21-三体综合征及18-三体综合征的检出率为5.3/万,假阳性率为10.69%.唐氏综合征高风险组胎儿异常的发生率高于唐氏综合征低风险组(P< 0.01 ).≥35岁孕妇组胎儿异常的发生率高于＜35岁孕妇组(P<0.05 ).结论 AFP、free-β-HCG可用于筛查唐氏综合征及胎儿异常.
Objective To evaluate the efficacy of screening for fetal Down＇s syndrome in the second-trimester by maternal serum biochemistry. Methods From July 1, 1996, to June 30, 2003, 13175 pregnant women at 14th-20th weeks gestation in Nanjing Women and Children Hospital were examined their maternal serum free {3-human chorionic gonadotrophin （Free-β-HCG） and α-fetopmtein （AFP） with the time-resolved immunofluorometric assay. At a risk cutoff value of 1：300, amniocentesis was done in those defined as risk cases. Results The detection rate of trisomy 21 and trisomy 18 by maternal serum markers was 0.053% （7/13175） ; false positive rate was 10.69%. Fetal abnormality rate in the high risk groups for fetal Downg syndrome was higher than those in the low-risk groups （P〈0.01）. Fetal abnormality rate in mothers who were ≥35 years old was higher than those in mothers 〈35 years old （P〈0.05）. Conclusion The AFP and free β-HCG can be useful markers to detect Down’s syndrome and fetal abnormality.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2005年第8期478-480,共3页
Chinese Journal of Practical Gynecology and Obstetrics
