摘要
目的观察肾衰患者血液透析对患者血管内皮细胞的影响.方法对2003-03～2003-11合肥医学院附属医院初次透析的终末期肾衰(ESRD)30例,分别于透析前、透析60、120min和透析结束时采血检测循环内皮细胞(CEC)数和von Willebrand因子(vWF).同时检测20例健康非透析成人的CEC和vWF.结果 ESRD患者CEC和vWF明显高于健康成人,透析过程中CEC和vWF进行性增高并且与透析时间呈正相关.结论 ESRD存在血管内皮层异常,血液透析可能加重血管内皮功能细胞损害.
Objective To investigate the effect of hemodialysis （HD） on the endothelial cells of the patients with endstage renal disease （ESRD）. Methods The study population consisted of 30 patients with undergoing first hemodialysis treatment and 20 healthy individuals from March to November of 2003. The number of circulating endothelial cells （CEC） and the concentration of yon Willebrand factor （vWF） were measured in HD patients at predialysis, lh during HD, 2h during HD, and the end of HD. CEC and vWF were observed in healthy subjects. Results CEC and vWF were increased in HD patients compared with healthy individuals, and elevated continuously during HD. Increased CEC and vWF were correlated significantly with duration of HD. Conclusion Endothelial cell dysfunction exists in the patients with ESRD. HD procedures may cause endothelial cell damage.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2005年第8期727-728,共2页
Chinese Journal of Practical Internal Medicine
