摘要
目的:探讨用血浆代用品6%贺斯(HAES)替代异体输血对肿瘤患者围术期免疫系统的影响。方法:将60例恶性肿瘤切除术患者,随机分为两组:输血组30例(B组);输贺斯组30例(H组)。分别于麻醉诱导前,术后第3天及第7天抽取患者外周静脉血,应用酶联免疫吸附法(ELISA)进行细胞因子sIL-2R和IL-2浓度的测定并以乳酸脱氢酶释放法进行NK细胞活性的检测。结果:sIL-2R两组均上升B组更为明显,差异显著(P<0.05);IL-2和NK细胞活性B组术后均明显下降(P<0.05),H组手术前后比较均无明显变化。结论:术中输异体血后抑制患者体内抗肿瘤免疫系统;而输贺斯则对体内抗肿瘤免疫系统无不良影响。
Objective： To investigate the effect of 6% hydroxyethylstarch replacing xenogenous blood tranfusion on perioperative immune system in patients with cancer. Methods： Sixty patients who underwent malignant tumor resection were randomly divided into two groups. In group B 30 patients were treated with blood transfusion and in group H 30 patients received hydroxyethylstarch infusion during surgery. The blood samples were collected before anesthesia and on the 3rd,7th clay after operation. Enzyme-linked immnosorbent assay （ELISA） is used to dected the level of slL-2R and IL-2, the cytoactive of NK cell were measured by the method of LDH release. Results： slL-2R increased in two group, but the amount of slL-2R was markedly increased in group B, on the 3rd and 7th clay after operation （P〈0.05）; I1-2 and the cytoactive of NK cell were markedly decreased after operation in group B （P〈0.05）, while there was not significant difference in group H. Conclusion： Perioperative xenogenous blood transfusion can depress inlnlune system in patients with cancer, hydroxyethylstarch did not affect immune system.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2005年第15期861-863,共3页
Chinese Journal of Clinical Oncology
关键词
输血
贺斯
免疫
Blood transfusion Hydroxyethylstarch Immunity
