摘要
目的:比较帕罗西汀与阿米替林治疗脑卒中后抑郁的疗效与不良反应。方法:将符合CCMD-Ⅲ标准的68例脑卒中后抑郁患者,随机分为2组,分别用帕罗西汀和阿米替林治疗6周。采用HAMD、HAMA、CGI量表评定疗效,TESS量表评定不良反应。结果:治疗2周后帕罗西汀组优于阿米替林组,6周后两组抗抑郁疗效无差异,抗焦虑效果帕罗西汀组优于阿米替林组。帕罗西汀组不良反应较阿米替林组少而轻。结论:帕罗西汀治疗脑卒中后抑郁效果与阿米替林相当,抗焦虑效果优于阿米替林,且起效较快,耐受性好,安全性高。
Objective： To compare the effectiveness and safety of paroxetine and amitriptyline in the treatment of the post-stroke depression. Method： 68 cases meeting the CCMD-Ⅲ criteria for the post - stroke depression were randomly divided into two groups to be treated for 6 weeks with paroxetine and amitriptyline respectively. HAMD, HAMA,CGI and TESS were used to assess the therapeutic efficacy and side effect. Result： The therapeutic efficacy of paroxetine was better than that of amitriptyline 2 weeks after the treatment. There was no significant difference in the two groups 6 weeks later. Paroxetine was superior to amitriptyline in anti-anxiety but paroxetine produced fewer side effects than amitriptyline. Conclusion ： Paroxetine is as effective as amitriptyline in the treatment of the post-stroke depression, and its effectiveness of anti-anxiety is superior to that of amitriptyline. Paroxetine is quicker in producing effectiveness, well tolerated and safer.
出处
《药物流行病学杂志》
CAS
2005年第4期207-209,共3页
Chinese Journal of Pharmacoepidemiology
