摘要
目的考察罗红霉素聚乳酸药膜的体外释药性能。方法采用紫外分光光度法测定溶液中罗红霉素的含量。测定波长为482nm。结果在不到三周的时间内,药物释放量超过80%。在最可能形成粘连的5-7d内,药物充分发挥了作用。结论该药膜对罗红霉素有一定的缓释作用,可用于防治术后粘连。
Objective To study the release ofpolylactic acid/roxithromycin membrane in vitro. Methods Ultraviolet-visible spectrophotometer was applied for analyzing roxithromycin concentration in the solution. The wavelength was 482nm. Results In less than 3weeks, the capacity of release overruned 80%. The roxithromycin was be used adequately in 5-7d when the adhesion easily formed. Conclu sio n The Polylactic acid / roxithromycin membrane showed significant sustained release effect and it can be used for prevention of postoprative adhesion.
出处
《生物骨科材料与临床研究》
CAS
2005年第4期9-11,共3页
Orthopaedic Biomechanics Materials and Clinical Study
