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CpG ODN诱导浆细胞样树突状细胞免疫调节的作用机制 被引量：3

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摘要 CpGODN是包含未甲基化的CpG基序的寡核苷酸,可以通过识别Toll样受体9(TLR9)诱导浆细胞样树突状细胞(PDC),促进其在归巢的同时由未成熟状态向成熟状态转化,并有效地提呈抗原,增加共刺激分子的表达,提供T细胞活化需要的第二信号;另外,CpGODN诱导PDC释放细胞因子IFN-α、同时在CD40L的协助下释放IL-12,由此引发T细胞向Th1方向分化和活化NK细胞,释放IFN-γ,启动先天性免疫和获得性免疫。对CpGODN的深入研究,将对抗感染、肿瘤免疫提供新的途径。
作者 胡向农 魏强
机构地区 四川大学华西医院泌尿外科
出处 《现代免疫学》 CAS CSCD 北大核心 2005年第4期337-340,共4页 Current Immunology
关键词 CPG ODN TOU样受体9 浆细胞样树突状细胞
分类号 R392.1 [医药卫生—免疫学]
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参考文献22

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同被引文献52

  • 1任晓勇,陈文弦,崔鹏程,张全安.中耳胆脂瘤上皮中白介素-1α的表达[J].中国耳鼻咽喉头颈外科,2005,12(6):367-369. 被引量：5
  • 2陈晓飞,邓敏.Toll样受体病原识别及信号转导的研究新进展[J].中国感染控制杂志,2006,5(3):282-285. 被引量：2
  • 3杨再兴,仲人前.Toll样受体3与自身免疫性疾病[J].现代免疫学,2006,26(6):520-522. 被引量：8
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现代免疫学
2005年 第4期

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