摘要
目的探讨补肾中药对膝骨性关节炎合并绝经后骨质疏松症骨密度及雌激素水平的影响。方法50例膝骨性关节炎合并绝经后骨质疏松症患者随机分成2组,分别给予补肾壮骨方冲剂和塞来昔布胶囊口服,疗程3个月,检测治疗前后症状积分、骨密度、性激素水平变化。结果治疗组治疗后绝经后骨质疏松症状积分、JOA积分均较治疗前有明显缓解(P<0.01),骨密度(BMD)、雌二醇(E2)均明显升高(P<0.01);对照组JOA积分均较治疗前有明显缓解(P<0.01),治疗后绝经后骨质疏松症状积分、BMD、E2均无明显改变(P>0.05)。结论补肾中药对膝关节骨性关节炎合并绝经后骨质疏松症有综合的治疗作用。
Objective To investigate the influences of kidney tonics on bone mineral density （BMD） and level of estrogen （E2） of osteogonarthritis combined with osteoporosis after menopause. Method The patients with osteogonarthritis combined with osteoporosis after menopause （ n = 50） were divided randomly into two groups and given respectively Bushenzhuanggu Granules and Celecoxib Capsules for 3 months. The symptom integral, BMD and level of E2 were detected before and after the treatment. Result In the treatment group the symptom integral, JOA integral were obviously alleviated （ P 〈 0.01 ） and BMD and level of E2 were increased （ P 〈 0.01 ） after the treatment then that before the treatment. In the control group JOA integral was obviously alleviated （ P 〈 0.01 ） but symptom integral, BMD and level of E2 were not changed after the treatment compared with that before the treatment （ P 〉 0.05）. Conclusion Kidney tonics have a synthetic therapeutic effect on osteogonarthritis combined with osteoporosis after menopause.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2005年第4期69-71,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家中医药管理局科学技术研究专项课题(No.02-03JP33)
广东省中医药管理局科研课题资助(No.103013)
关键词
补肾中药
骨性关节炎
骨质疏松症
骨密度
雌激素
kidney tonics
osteogonarthritis
osteoporosis
bone mineral density
estrogen （E2）
