摘要
本文以大鼠游离肝细胞半数中毒浓度（ＴＣ_（５０））对镉、硒、铜、砷、锑、汞、锌、铅、铬、镍１０种金属组成２９个配对进行了联合毒性的研究。结果表明：１０种金属化合物肝细胞毒性大小顺序是汞＞镉＞铅＞砷＞锑＞铜＞铬＞镍＞锌＞硒，与体内肝毒性顺序基本一致。汞、镉、铅三种金属之间有增毒作用，对其它金属的毒性亦有增毒作用。锌可以拮抗镉、铅、铜的毒性作用，硒可以拮抗汞、镉、砷对细胞的毒性，其余金属配对呈毒性相加作用。铬和砷对镉的细胞毒性表现为拮抗作用，其机理需进一步进行研究。
his study used isolated rat hepatocytes to investigatethe joint toxic action of Cd ,Se,Cu, As,Sb,Hg,Zn Pb, Cr,Ni.Evidence of cellular injury was assessed by mediantoxic concentration(TC50). The results indicate:(1)theorder of the toxic potency in ten metal is Hg>Cd>Pb>As>Sb>Cu>Cr>Ni>Zn>Se;(2)there is synergic toxicaction between Hg-Cd and Cd-Pb; (3)Zn has protectiveeffect against Cd and Pb,Se can protect against toxic potency of Cd and As;(4)the joint toxic action of other metal pairs is addition action.
出处
《环境与健康杂志》
CAS
CSSCI
CSCD
北大核心
1995年第2期56-58,共3页
Journal of Environment and Health
