摘要
氨基膦酸生物活性的发现,推动了这类氨基磷酸类似物合成方法的研究。我们曾仔细考察过在醛、羰酰胺与亚磷酸酯的反应中,试剂结构的改变对产物得率的影响。
A novel method for the synthesis of a-aminophosphonic acids based on the reaction of triphenyl phosphite on symmetric N, N＇-alkylenebiscarboxamide or N-hydroxyca- rboxamide followed by subsquently hydrolysis was reported. Based on the experimental observations, a tentetive reaction mechanism involving an electrophilic attack by biscarbo- xamide on the trivalent phosphorus was suggested. It is helpful for the understanding of the reacticn pathway of carboxamide aldehyde and phosphite leading to the formation of a- aminophosphonic acids. An improved synthetic method for biscarboxamide was achieved, The characteristic behaviours in fragmentation of biscarboxamide in mass spectra were discu- ssed.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1989年第2期136-140,共5页
Chinese Journal of Organic Chemistry
