摘要
观察大厂矿尘在体内实验和体外实验对肺泡巨噬细胞(PAM)的影响。结果表明大厂矿尘对PAM具有细胞毒性且存在一定的剂量效应关系。提示PAM的功能减弱甚至死亡,导致机体的非特异免疫功能减弱,可能有利于肺癌的发生和发展。
An Experimental study was performed in vivo and in vitro to investigate the cytotoxicity of dachang mine dust on the pulmonary alveolar macrophages (PAM). The results show that the mine dust is not only cytotoxic but also possesses a dose-effect relationship. The functions of PAM are weakened or even abolished, leading to the hypofunctiou of the nonspecic immunity. And this may promote the occurence and development of lung cancer.
出处
《广西医科大学学报》
CAS
1995年第4期496-498,共3页
Journal of Guangxi Medical University
关键词
旷尘
细胞毒性
肺泡巨噬细胞
mine dust
cytotoxicity
pulmonary alveolar macrophage
