摘要
对６只家兔单用氨茶碱和氨茶碱合用甘草的药代动力学资料作对比研究发现：合并用药后，氨茶碱的ｔｌ／２β缩短（从３．４２±０．６３ｈ降至２．６６±０．３３ｈ）（Ｐ＜０．０５），曲线下面积减少（从１０７．６４±１１．９２降至６１．６３±７．８８μｇ·ｈ／ｍｌ（Ｐ＜０．０１），并使清除率从０．１４±０．０２增至０．２１±０．０３ｌ／ｋｇ·ｈ（Ｐ＜０．０１）．结果表明：甘草可影响氨茶碱的动力学，促进氨茶碱的消除速率，缩短消除半衰期。
Effects of Glycyrrhiza uralensis on the aminophylline kinetic were studied in six rabbits,The means of aminophylline elimination half-life was shortened from 3.42±0.63h to 2.66±0.33h(P<0.05),the area under curve of aminophylline decreased from 107.64±11.92μg·h/ml to 61.63±7.88μg·h/ml.Aminophylline clearance increased from 0.14±0.02l/kg·h to 0.21±0.03l/kg·h.The results indicated that Glycyrrhiza uralensis could change aminophylline kinetics,increase the clearance of aminophylline,and reduce aminophylline elimination half-life.
出处
《广东医学院学报》
1995年第3期201-204,共4页
Journal of Guangdong Medical College
关键词
氨茶碱
甘草
兔
药物动力学
合理用药
aminophylline/metabolism
Glycyrrhiza uraliensis
pharmacokinetics
rabbit
