摘要
微电泳导入5-HT拮抗剂赛庚啶(Cyproheptadine,Cyp)至丘脑束旁核(Pf),观察Cyp对Pf伤害性神经元放电的影响.结果表明,Cyp能增加Pf伤害性神经元的自发和诱发放电。提示Cyp能阻断内源性5-HT对Pf伤害性神经元自发和诱发放电的抑制作用.
Experiments were performed on 25 rats. Putative serotonergic antagonist, Cy-proheptadine ( Cyp) , was applied microiontophoretically on the nucleus parafas-cicularis of the thalamus ( Pf) and the effect of Cyp on Pf nociceptive neuronal discharge was observed. The result suggested that Cyp can increase the spontaneous and evoked discharge rates of Pf nociceptive neuron, and that Cyp may antagonize inhibitory effect of endogenous serotonin on the spontaneous and evoked discharges of Pf nociceptive neurons.
出处
《第一军医大学学报》
CSCD
1989年第4期316-318,共3页
Journal of First Military Medical University
关键词
束旁核
赛庚啶
伤害性电位
微电泳
cyproheptadine
serotonin
nucleus parafascicularis
nociceptive neuron
microiontophoresis
