摘要
本研究利用ＱＵＡＮＴＩＭＥＴ—９７０图象分析仪对２６例胆管癌细胞核形态学进行了测定。并探讨了胆管癌细胞核形态学与其ＴＮＭ分期、组织病理学分级、肿块大小、浸润性和淋巴转移等生物学行为的关系。研究结果表明：胆管癌细胞核内ＤＮＡ含量和异型性的大小可作为判断其预后的客观指标；胆管癌肿块的大小与其癌细胞核内ＤＮＡ含量成正比，且与ＤＮＡ分布有关；胆管癌细胞核的异型性和ＤＮＡ分布为探讨不同性别患者的胆管癌发病率提供了一个线索；胆管癌细胞核ＤＮＡ倍体与其术后生存率的关系尚需进一步研究。
The nuclear morphology of 26 cases with cholangiocarcinoma was investigated by means of QUANTIMT-970 Cell Image Analyzer,The relationship between the nuclear morphology and the biological behaviors such as TNM stage,histopathological grade,size of tumor,invasion and Lymph node involvement were explored in this paper. The results show that DNA content and pleomorphism of the nucleus of the cancerous cell are of two prognostic factors.The size of tumor is positively propositioanl to DNA content of the nucleus.Pleomorphism and DNA distribution pattern may be considered as a clue for further exploration of the different incidences of cholangiocarcinoma in the male and the female,The relationship between DNA ploidy and the postoperative survival is required further investigation.
出处
《肝胆外科杂志》
1995年第2期114-118,共5页
Journal of Hepatobiliary Surgery
关键词
胆管肿瘤
细胞核
形态学
生物学行为
Cholangiocarcinoma
Nuclear Morphology
Cell Image Analyzer
Biological Behavior Prognosis
