摘要
以ELISA检测31例急性乙型肝炎患者的前S_2抗原,24例阳性,检出率77.4％。前S_2抗原最早出现于第一病日,最迟检出的一例在第23病日。22例(91.6％)该抗原于发病后4周内消失,2例在病后24周仍持续阳性。前S_2抗原与抗-HBcIgM阳性,高滴度HBsAg,HBVDNA和HBeAg阳性及ALT异常有关,因而它是乙型肝炎病毒复制的另一标志。前S_2抗原的持续可能表示肝炎有慢性化趋势。
Serum pre-s2 antigen of 31 patients with acute hepatitis B were 'detected by ELISA. Twenty-four(77.4%) of these patients were positive for pre-s2 antigen. Pre-s2 antigen was detected in serum of the patients within 1-4 weeks after the onset. Pre-s2' antigen of 22 cases(91.6%) disapeared 4 weeks after the onset of the acute illness. Two patients were persistently positive the sixth months after the onset. Serum pre-s2 antigen was related to anti-HBcIgM, high titer of HBsAg, HBV-DNA and abnormal ALT. So it is believed that pre-s2 antigen is another marker of viral replication. The persistence of pre-s2 antigen tends to be chronic.
出处
《第四军医大学学报》
1989年第5期306-308,共3页
Journal of the Fourth Military Medical University
关键词
乙型肝炎
乙型肝炎病毒
抗原
hepatitis B
hepatitis B virus
antigens, viral
