摘要
观察了10对21—三体患儿的23～34岁父母的外周血淋巴细胞G显带染色体随体(S)联合率,另对相应年龄内的正常夫妇和曾流产3次及有流产、死胎史以及生产过其他类型畸胎者夫妇各10对作了观察比较。结果:21—三体患儿双亲组的染色体21-D及21-G的S联合率明显高于其他4组(P<0.01)。初步认为:年轻夫妇的21-D及21-G S联合率增高者,生育21—三体患儿的可能较大,应仔细作产前诊断,防止21—三体患儿诞生。
The rale of satellite association was studied in G-handed chromosomes of peripheral lymphocytes of 10 young couples from 23 to 3.1 years of age who had given birth to trisomy 21 offsprings. The results were compared with those observed in the following 4 groups of couples, each of which included 10 couples of similar age as mentioned above (1) couples with normal offsprings, (2) couples with 3 consecutive spontaneous abortions, (3) couples with spontaneous abortions and stillbirths and (4) couples with anomalous offsprings other than trisomy 21. The rate of satellite association of 21-D and 21-G in couples with trisomy 21 offsprings was significantly higher than those in the other 4 groups (P<0 .01). Our preliminary suggestion is that if the rate of satellite association of 21-D and 21-G is elevated in young couples, the possibility of having trisomy 21 offsprings in the future should be taken in account and it would be necessary to make a prenatal diagnosis in order to prevent the birth of a trisomy 21 children.
出处
《第四军医大学学报》
1989年第4期251-253,共3页
Journal of the Fourth Military Medical University
关键词
21三体综合征
染色体
随体联合率
trisomy 21
chromosome
rate of satellite association
rate of 21-D and 21-G satellite association
nucleolar organizer region
