摘要
观察滋养细胞肿瘤患者及治愈后生育子女的外周血染色体脆性部位及畸变率。结果表明滋养细胞肿瘤患者的染色畸变率和脆性部位表达频率均明显高于对照组。尤其是脆性部1p32、2q31、3p14、7q32、14q24及16q22表达频率明显增加。化疗治愈后生育子女的染色体畸变率及脆性部位表达频率均与对照组无区别。
Chromosomal aberrations and fragile sites were studied in metaphases from peripheral blood lymphocyte cultures of 68 subjects, of whom Group A-15 normal women, Group B-16 not treated patients with GTT. Group C-11 women with GTT chemotherapeutically cured, Group D-12 normal children and Group E-14 offsprings of 11 cured women with GTT. The results showed that the chromosomal aberration rate of the patients (19.63%) was significantly higher than that of the normal women (7.0%) . G-banding analysis in situ revealed that 241 breaks and gaps were consistant with the common fragile sites. The 45 breaks and gaps were at the same locations as some oncogenes.
Comparing the chemotherapeutically cured patients with the controls and the offsprings of the cured patients with normal children, we found that their chromosomal aberration rates were not significantly different.The results suggest that chemotherapy be not likely to damage the genetic material of the patients and their offsprings.
出处
《遗传与疾病》
CAS
CSCD
北大核心
1989年第1期6-8,63+68,共3页
