摘要
作者应用放免分析法对２４例十二指肠溃疡（ＤＵ），１５例胃溃疡（ＧＵ）患者胃、十二指肠粘膜进行了生长抑素（ＳＳ），精氨酸加压素（ＡＶＰ）、脑啡肽（ＥＫ）和β－内啡肽（β－ＥＰ）含量测定．同时以２０例慢性浅表性胃炎（ＣＳＧ）为对照．结果表明，ＤＵ患者球、窦和体部粘膜ＳＳ含量（依次为１５３．５±２７．５，３３０．９±２３．９和１７７．１±３０．９ｐｇ／ｍｇ）显著低于（Ｐ＜０．０５）对照（依次为２５３．７±３４．２，５８８．９±８５．３和２８８．８±４０．５ｐｇ／ｍｇ），ＥＫ（依次为９８．６±１３．２，１０８．２±１６．５和５８．５±１０．３）和β－ＥＰ（依次为１１３．０±２２．６，８８．７±１６．８和８２．８±１８．８ｐｇ／ｍｇ）显著高于（Ｐ＜０．０１）对照（ＥＫ依次为５０．１±８．８，６２．９±１１．４和３０．９±３．０；β－ＥＰ依次为８２．３±８．１，３９．８±６．８和４９．８±９．１）．ＤＵ患者球部粘膜ＡＶＰ（５２．３±７．０ｐｇ／ｍｇ）显著高于（Ｐ＜０．０５）ＣＳＧ（３７．７±４．３ｐｇ／ｍｇ）．ＧＵ组上述激素含量与对照组比较均无显著差异．提示：①ＡＶＰ，ＳＳ，ＥＫ和β－ＥＰ在人胃、十二指肠皆有分布；②粘?
The
contents of somatostatin(SS),argovasopressin(AVP),enkephalin(EK)and β-endorphin(β
-EP)were determined by means of radioimmunoassay in mucosa biopsied from the fundus and
antrum ofstomach,and duodenal bulb in 24 patients with duodenal ulcer (DU),15 gastric ulcer
(GU),and 20 chronicsuperficial gastritis (CSG).In DU group,levels(pg/mg wet tissue as follow) of
SS in fundus(177.1±30.9),antrum(330.9±23.9),and duodenal bulb(153.5±27.5) was
significantly decreased (P<0.05)compared to that in CSG(288.8±40.5 in fundus, 588.9±85.3 in
antrum and 253.7±34.2 in duodenal bulb),respectively. Levels of EK and β-EP in the
fundus(58. 5±10.3 and 82.2±18.8),antrum (108. 2±16.5 and 88.7±16. 8) ,and duodenal
bulb(98.6±13. 2 and 113.0±22.6)were remarkably increased (P< 0.01)compared to those in
CSG(30.9±3. 0 and 49.8±9. 1 in fundus, 62.9±11.4 and 39.8±6. 8 in antrum,and 50.1±8.8
and 82.3±8. 1 in duodenal bulb),respectively. In duodenal bulb of DU,the content of AVP(52.3
±7.0)was significantly higher than that in the CSG (37.7±4.3P<0.05).But the same re-sult was
not obtained in patients with GU (P>0. 05).It is suggested that:(1)immunologically reactive
SS,AVP,EK and β-EP are all widely distributed in gastroduodenal mucosa of adult human
subjects;(2)lower level of SS and higher levels of AVP, EK and β-EP in the gastroduodenal
mucosa may be associated with the pathogenesis of DU;(3) higher levels of AVP, EK and β-EP
may be related to reduction of SS in gastroduo-denal mucosa.
出处
《第四军医大学学报》
1995年第3期208-210,共3页
Journal of the Fourth Military Medical University
关键词
胃肠激素
消化性溃疡
生长抑素
精氨酸加压素
gastrointestinal
hormones
peptic ulcer
omatostatin
argovasopressin
enkephalin
β
-endor-phin
radioimmunoassay
