摘要
本文用红外光谱法测定了甲苯咪唑中晶型C的含量。取高铁氰化钾细粉(6mg)为内标物,与样品细粉(30mg)在0.25ml液体石蜡中仔细研磨均匀。将糊状物放入0.1mm铅片隔开的KBr窗片之间,分别于800～850cm^(-1)和2050～2150cm^(-1)以吸收度的方式扫描谱图。最后以834和842cm^(-1),2114和2140cm^(-1)吸收度之差按内标法计算甲苯咪唑C型晶型的百分含量。该法对甲苯咪唑原料和片剂都适用,操作简便、专属性高,结果满意。
Mebendazole displays polymorphism. There are three polymor phic forms (A, B and C) which were identified by means of IR and X-ray diffraction techniques.Procedures have been worked out to determine the amount of the polymorphic form C in pure mebendazole and in tablets. The sample (30 mg) and internal standard (K_3Fe(CN)_6, 6 mg) were mulled in 0.25ml of mineral oil and placed between KBr plates separated by a 0.1 mm lead spacer. The spectra were recorded by the absorbance mode between 850～800cm^(-1) and 2150～2050 cm^(-1). Both of the base lines are the horizontal line from 2140 cm^(-1) peak valley and from 842 cm^(-1) peak valley.The values of theabsorbance difference were measured at 834 and 842 cm^(-1), 2114 and 2140 cm^(-1) respectively. The percent content of the polymorphic form C was calculated by the method of internal standard. This analytical approach is simple and the results are satisfactory.
出处
《药学学报》
CAS
CSCD
北大核心
1989年第12期932-936,共5页
Acta Pharmaceutica Sinica
关键词
甲苯咪唑
C型晶型
红外光谱
Infrared spectrometry quantitation
Mebendazole
Mebendazole polymorphic form C
