摘要
１５名西安地区乙脑患者，平均年龄３岁．在患者志愿接受鼠源性ＭＣＡｂ治疗，以及ＭｃＡｂ制剂严格按照质控标准制备的前提下，静脉一次给予５ｍｇ鼠源性乙脑ＭｃＡｂ。于给药后当时、第３天、第７天、第１０天及第１４天分别来血，测其ＭＣＡｂ浓度和有无抗鼠ＩｇＧ抗体产生。结果显示给药后当时血中ＭｃＡｂ浓度为１μｇ／ｍｌ，血中浓度半衰期为４天；到第１０天体内ＭｃＡｂ为０．０１μｇ／ｍｌ。１５例患者中有２例在第７天产生抗抗体，１例在第１０天，１例在第１４天测到抗抗体．其余１１例在第１４天仍未测到抗抗体产生。
Japanese encephalihs patientS'blood were collected at the 3rd hour, 3rd day,7th day,10thday,and 14th day after receiving 5 mg of JEV McAb by i,v. The murine McAb IgG was purified andqualified according to the standard of quality control for the use of murine McAb in human body issued by the Ministry of Health.We obtained a curve in which JEV--McAb concentration in blood was1μg/ ml at 3rd hour,0.7μg/ ml at 3rd day,0.15 μg/ ml at 7th day after administration of theMcAb,and it was found the half-life of JEV-McAb in blood was 4 days. Another result showed thatanh- McAb antibody could be detected by ELISA in 4 patients while the others were negative.
关键词
乙型脑炎
鼠源性
单克隆抗体
日本脑炎
antibody,murine monoclonal
dynamics
Japanese encep17alitis
