摘要
麻醉大鼠结扎ＬＡＤ（ＬｅｆｔＡｎｔｅｒｉｏｒＤｅｃｅｎｄｉｎｇ）引起急性心肌梗死，在ＬＡＤ结扎后５小时取血测定ＣＰＫ、ＦＦＡ及ＰＧＩ-２、ＴＸＡ-２；，并作心肌ＮＢ－Ｔ染色测量心肌梗死面积。结果显示健心康具有抑制ＬＡＤ结扎后血清ＣＰＫ、ＦＦＡ升高，增加血浆中ＰＧＩ-２／ＴＸＡ-２比值，缩小心肌梗死面积的作用。
In the model of myocardial infarction produced by occlusion of left anterior decending coronary artery (LAD) in rat, JianXinKang reduced myocardial infarct size and decreased serum free fatty acid(FFA) and creatine phosphate kinase(CPK) and increased 6-keto-PGF 1α/TXB-2 ratio.The results indicate that the protective effect of JXK on myocardial infarction may be correlated with the amelioration of FFA metablolic deterioration, and attributed to increasing PGI-2/TXA-2 ratio.
出处
《大连医科大学学报》
CAS
1995年第2期96-99,共4页
Journal of Dalian Medical University
关键词
血栓素A
心肌梗塞
健心康
JianXinKang
myocardial infarction
prostaglandins X
thromboxane A
