摘要
本文采用ＳＯＤ／ＬＰＯ比值这一指标观测了不同年龄组健康成人ＳＯＤ／ＬＰＯ比值的变化及冠心病、糖尿病及肿瘤患者对这一指标的影响。结果表明：正常人ＬＰＯ水平随年龄逐渐增高，而ＳＯＤ活性逐渐下降，ＳＯＤ／ＬＰＯ比值显著下降。冠心病、糖尿病患者比正常组ＬＰＯ水平更高，ＳＯＤ活性更低，尤其ＳＯＤ／ＬＰＯ比值下降显著，而肿瘤患者的ＬＦＯ、ＳＯＤ变化更为显著。这提示自由基增加是冠心病、糖尿病及肿瘤患者的发病机理之一。
The SOD/LPO ratio has been used as a new marker to reflect the relationship between preoxidation and antioxidation. The chages of SOD/LPO ratio have been investigated in healthy persons and patients. The results showed the levels of human RBC LPO increased with age, and the SOD activities decreased, the SOD/LPO ratio greatly decresed with age,In contract to the control group, the LPO levels were much higher in coronary heart diseases patients and diabetes patients, while the SOD activities much lower. Especially,SOD/LPO drops markably, and much markably than those of the control group in cancer patients.This suggests that free radical may be an important factors in those diseases.
出处
《大连医科大学学报》
CAS
1995年第2期100-101,115,共3页
Journal of Dalian Medical University
