摘要
用ＥＬＩＳＡ方法检测结核性和非结核性（癌性及漏出液）胸腹水及血清中的可溶性白细胞介素—２受体（ｓＩＬ—２Ｒ）。结果显示：结核组ｓＩＬ—２Ｒ水平明显增高（４２３８±１８４３ｕ／ｍｌ），与癌性胸腹水组（１３０９±５６５ｕ／ｍｌ）及漏出液组（６５４±４０８ｕ／ｍｌ）比较有极显著性差异（Ｐ＜０．００１）。与胸水中腺苷脱氨酶活性（ＡＤＡ）呈正相关（ｒ＝０．６８８，Ｐ＜０．００１）。敏感性及特异性均为９０％。提示检测胸腹水的ｓＩＬ—２Ｒ对于结核性胸腹水的诊断及鉴别诊断有重要意义。
The levels of soluble interleukin-2 receptor(sIL-2R ) were determinedby the
ELISA in pleuroperitoneal fluid and serum from 30 cases of tuberculous pleurisy,30 cases of
carcinomatous pleuroperitonitis and 27 cases of transudate.The sIL-2Rlevels were sighificantly
increased in tuberculous pleural fluid ( 4238±1843u/ml)ascompared with those in
carcinomatous pleuroperitoneal fluid(1309±565u/ml ) and intransudate(654±408u/ml).In
patients with tuberculous pleurisy ,the level of sIL-2R inpleural fluid was markedly higher than
that in serum.A significant positive correlationwere Observed between the sIL-2R levels and
adenosine dearminase activities intuberculous pleural fluid.Fixing the cutoff points of sIL-2R
values at 2500u,2000u and1500u ,the tuberculous pleural effusions were differentiated form the
nontuberculous,with a sensitivity ,specificity ,postive predictive value,negative predictive
value andsafety diagnosis of over 90 percent.
出处
《承德医学院学报》
1995年第3期216-219,共4页
Journal of Chengde Medical University
基金
1992年院级课题
关键词
胸水
腹水
白细胞介素2
受体
鉴别诊断
水胸
soluble interleukin-2
receptor
adenosine deaminase
tuberculouspleural effusion
